COMPREHENSIVEEVALUATION OF THE EFFECTIVENESS OF 3-HYDROXYPYRIDINE HEMISUCCINATE WITH CHRONIC HEART FAILURE BY RATS

Zamotaeva Mariya Nikolaevna, Candidate of medical sciences, senior lecturer, sub-department of pharmacology with the course of clinical pharmacology, Mordovia State University named after N. P. Ogaryov (Saransk), zamy03@mail.ru
Inchina Vera Ivanovna, Doctor of medical sciences, professor, sub-department of pharmacology with the course of clinical pharmacology, Mordovia State University named after N. P. Ogaryov (Saransk), vinchina03@mail.ru
Chairckin Ivan Nikolaevich, Doctor of medical sciences, professor, head of sub-department of normal anatomy, Mordovia State University named after N. P. Ogaryov (Saransk), Chairkin@rambler.ru
Drozdov Ilya Alexandrovich, Postgraduate student, Mordovia State University named after N. P. Ogaryov (Saransk), drozdov-i1ya@mail.ru
Kuzmichyov Nikolay Dmitrievich, Doctor of physical and mathematical sciences, professor, head of sub-department of general scientific disciplines, Mordovia State University named after N. P. Ogaryov (Saransk), kuzmichevnd@mail.ru
Kuznetsov Yury Vasilyevich, Candidate of chemical sciences, senior staff scientist, Institute of biochemical physics named after N.M. Emanuel of the Russian Academy of Sciences (Moscow), drk2001@mail.ru

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The authors conducted an experiment estimating the effect of Mexidol and 3-oxipiridin hemisuccinate on chronic catecholamine damage of the myocardium in rats. The 3-oxipiridinhemisuccinate in doses of 22mg/kg was found to decrease the ex-pressiveness of structural changes in the myocardium, developments of stagnation in the liver and lungs, and to increase the contractility of the myocardium, to normalize the rate of heart contractility and to decrease biochemical shifts at durable chronic.

antioxidants, Mexidol, lipid peroxidation, chronic durative heart defi-ciency, 3-oxipiridin.